THE USES OF FUNGI. 193 It has been proved that ordinary vinous fermentation always involves the formation of yeast: the more yeast, the quicker the fermentation. How by their growth these living organisms become the sources for the ferments proper, which are considered by scientists to be really only chemical substances pure and simple, has not yet been ascer- tained. All we know is that, in the presence of certain substances, yeast appears; and that with its multiplication—by simple "gem- mation," or budding, be it noticed, and not by sporification, which is never observed—fermentation takes place. Whence the yeast comes it is beyond our power to say, save that germs capable of its reproduction must be carried by the air. According to Pasteur's experiments and observations, the yeast which forms spontaneously in grape-juice is derived chiefly from certain germs which abound about harvest-time on the grapes, and still more on the grape-stalks. These germs are largely diffused also through the atmosphere of breweries, wine-cellars, and laboratories where fermentation experi- ments are carried on ; but they are not by any means widely diffused through the atmosphere generally. It is not, however, only as the means by which mankind obtains wine and beer and whiskey that yeast is such an important economical factor. It is to the properties of yeast that we owe almost all the bread which we ordinarily eat. The generation of carbonic acid gas caused by yeast has indeed been imitated by art, and dough can be impregnated with the gas by purely mechanical means, as in the so-called "aerated bread," or by the interaction of certain chemicals in the form of "baking-powders." But by far the larger proportion of the bread consumed in England is spongified and made light and digestible by the action either of brewers' yeast, or of the "German yeast" obtained from the fermentation of wine. Before I have done with yeast, I must call your attention to the fact that it has a place in the British Pharmacopoeia, where directions are given for making a "yeast poultice," cataplasma fermenti, as it is there called. In Dr. Garrod's classical work on Materia Medica the therapeutical uses of yeast are thus summarized: "Yeast, when externally applied, acts as a stimulant and antiseptic, and in the form of cataplasm or poultice is employed to correct the discharges of indolent ulcers. Internally it has been used in low states of the system, in which it is stated to clean the tongue and correct the foetor of the alvine discharges, to prevent the formation of boils and carbuncles, and as a remedy L