28 PLANT DISEASES AND FUNGI. to no remedy for everything which shall be "worth a guinea per box." Morison's pills are not yet invented which shall cure apple scab, potato rot, or vine mildew. Empirics may arise, but empiricism will effect no cure, except by accident. As there is no royal road to knowledge in general, so there is no royal road to knowledge in this particular instance, and no universal cure. It must be borne in mind that there are at least two classes of fungoid diseases, viz., those which are epiphytal, growing upon the plant from the outside, and those which are endophytal, or developed from within the tissues of the affected plant. Necessarily the means adopted for the cure must have regard, first of all, to the one of the two classes to which the fungus belongs. The epiphytal kinds are represented by our ordinary vine mildew, by the hop mildew, by the mildew of peas, by all those in which a web-like mycelium of delicate threads spreads over the surface of the leaves, chokes up the pores, prevents the ingress or egress of air, and suffocates the plant. In such diseases the destruction of the fungus must be attempted in such a manner as not to injure the host plant. This may be done by the application of fungicides, and especially by the application of sulphur. It was the discovery of this remedy which greatly mitigated the disease in the hop and vine mildew, and is known to be the most beneficial in any case of similar infection, but it is useless when applied to fungi of the other class, which are endophytal, and must be treated in a different manner. Another remarkable analogy here is presented in the treatmeut of plants and animals. A short treatise by Dr. Valen- tine Knaggs on "The Cure of Diphtheria by the Frequent Administra- tion of Small Doses of Sulphur," affords this analogy. He says: "More than five years ago my father employed sulphur with magical effect in a case which was at that time regarded as desperate. The severity of the symptoms were hourly increasing under carbolic and other applications; but by the sulphur treatment, employed in the manner I here advocate, the patient made a rapid recovery. Since that time both my father and I have treated similarly seventy-two cases, in all of which diphtheritic deposit was unmistakably and mark- edly present. Though many of them were of a severe character, some even with laryngeal complication, and accompanied by lividity of skin, yet in not a single instance has a fatal termination occurred, and in remarkably few of them have any of the ill effects which are so apt to follow this complaint, even in the mildest and most transient forms, resulted." Further on, and incidentally, he says: "Sulphur