PERIODICITY IN ORGANIC LIFE. 53 numbers; when it would be an illustration of the phenomenon of periodicity, to which I am now calling attention. Periodicity in abundance is not confined to any class in organic life ; it occurs in the highest as well as in the lowest, and I propose to illustrate my meaning by taking examples first from the lowest forms of life and afterwards from the higher. Epidemic diseases are, in all classes of organic life, due to a germ; this theory is, I think, now universally acknowledged. The disease germ, then, shall be our first example, and as there is one disease which will enable me to make my ideas on this subject of periodicity more plain and clear perhaps than any other, I will take that first. For many years, ages almost, there existed in the neighbourhood of Boulogne a disease which was known to the French physicians by the name of "Diphtherite," and to many of our countrymen who visited that district as "Boulogne Sore-throat." Possibly there may have been cases in this country also, and perhaps elsewhere in Europe, but if so, the cases were so few in number that they attracted little or no attention. Here, then, we have this species of germ at its rare or almost extinct period; it existed, but it was not prolific. In 1852 or thereabout cases began, though rarely, to occur in various parts of Britain, but they did not spread, and never became epidemic. Gradually, however, more and more was heard of them—the germ was approaching its period of activity — and at last, in 1858, Diphtheria, for this was the disease, overran not only Europe but the whole world. This was the period of the abundance of the Diphtheria germ, but, happily for mankind, its period of rarity seems approaching. It is not so virulent (although even now bad enough), nor is it so spreading as in its period of prolifieness and abundance. This disease also enables me to illustrate the fact that man's proceedings neither caused the sudden increase in the number of attacks, nor did he in any way diminish them, excepting that by care, and the adoption of the teachings of sanitary science, he, to a certain extent, protected some portions of the population, and in individual cases placed the affected in a better position to resist the ravages of the disease. But he certainly did not bring about the diminished virulence which was so apparent after the disease had existed for some time, any more than he can be said to have made the disease epidemic in the first instance. It will no doubt be said