THE PRESIDENTIAL ADDRESS. 17 It is not alone a most fascinating study, throwing a flood of light on most obscure problems of vegetable physiology, but it is also of immense practical importance in the manuring of crops. It is, at least, possible that the mere unintelligent application of the constituents needed for plant life may in some cases do more harm than good by discouraging the efforts of these invaluable living auxiliaries. As we get higher in the scale of life, the influence of lower forms becomes of even greater importance. In medicine, instead of being able, as we seemed to have the prospect of being, to regard the body a highly-developed chemical laboratory, the processes of which were more or less analogous to those known in the work-shop of the chemist, we find that health or sickness, life or death, depend to an undetermined degree on the life- history of micro-organisms, the very existence of which we did not guess a few years ago ; it is the culture in the flask of the bacteriologist rather than the re-action in the test-tube of the chemist that tells the secret of disease and its cure. It is the foes within the human frame far more than the foes without that imperil it. Time would fail to follow out the ramifications of this wide question. I will but remark on the fact that while we are thus constantly meeting fresh proofs of the all-prevailing influence of living organisms, we seem as far off as ever from learning what life is. It certainly is not organic in the sense of depending on the presence of organization ; it is the living "protoplasm" that makes the organization, not the organization that makes the life, but how to express in terms that we can comprehend what is the real difference between living and dead matter is a problem as obscure as ever. We do but learn the more we know how little we know and realize how much there is to learn, how much more to believe.