248 BACOT: MOSQUITOES AND THE DANGER OF MALARIA. recent writer suggests that, among other purposes, it is of service to wash out any film of blood that may remain in the tube after feeding. The irritation which follows the bite of mosquitoes and other blood-sucking insects is probably due to the action of the salivary fluid, and may be only incidental to its action for these purposes. The broad facts suggest, however, that this irritation is purposive and is associated with the dilation of the very small blood vessels or capillaries, thus producing a readily- available supply of blood within the radius of the insects' suction. Schaudin suggested that the weal produced by mosquito-bites was caused by an enzyme due to the presence of yeast organisms in the diverticula of the oesophagus. Weals are, however, some- times produced by the bites of bugs, lice, or fleas, which do not possess diverticulae of the oesophagus and whose stomachs appear normally to be relatively, if not actually, sterile. III.—MOSQUITOES AND THE DISSEMINATION OF DISEASES. Our present exact knowledge of the part taken by mosquitoes in transmitting disease is due to many devoted workers, among whom may be mentioned Grassi, Laveran, Manson, and Ross in regard to Malaria ; to the members of the United States Army Commission, Drs. Reed, Carol, Lazear, and Agramonte in the case of Yellow Fever ; and to Manson as regards Elephantiasis. The connection between mosquitoes and disease had. however, been suspected and written about by earlier workers on tropical diseases during the nineteenth century ; while, as a popular belief, it was current in widely-separated countries from very early times ; for the device of mosquito curtains was known to, and used by, the ancient Egyptians. As a result of the labours of Ross and numerous later workers. it is now established that Malaria fever is transmitted by certain species of mosquitoes belonging to the section Anopheles only. Consequently, it is of great practical importance that all the special characters of this group should be carefully studied and that the distinctive features which separate them in egg, larval, and adult stage from the other tribes of mosquitoes should be clearly charted. In Britain, the commonest and most important species of Anopheles is A. maculipennis (figs. 2 and 3, Pl. v.). We have, however, another species of Mosquito (Theobaldia annulata) (figs. 4 and 5, Pl. v.) which bears some superficial