HISTORY IN BOTANICAL STUDY. 107 finds no indication that, for more than twenty years after the death of the Countess, that name was used for the drug outside Spain and as little evidence that during these twenty years it was used in Spain. In 1621, the year the Count of Chincon married Ana d'Osorio, a talented young Jesuit priest, Juan de Lugo, member of an influential family of Seville, was called to Rome to fill a professor's chair. He had reason to be interested in the countries then termed by the people of Spain "Nuestras Indias Occidentales," because his elder brother, Francisco, had been since 1600 a Jesuit missionary in Mexico. Juan de Lugo rose to be the Superior of his Order, and could thus have become aware of the existence in Peru of the remedy against malaria supplied by Barnabe de Cobo in 1632. On 14th December, 1643, Juan de Lugo was made a Cardinal, by which date the Count of Chincon had succeeded in establishing the export of Cinchona Bark to Spain. At that date the town of Seville enjoyed the monopoly of trade with Peru; the influence of his family in that town enabled the Cardinal to secure supplies of Cinchona Bark, which he made it his practice, from the time of his election to the Sacred College until his death on 20th August, 1660, to distribute free to the poor, while recouping himself by selling it at exorbitant prices to the well-to-do. Whether, during this period, the new drug was, or was not, spoken of by the poor in Spain as Countess's Powder, there is no doubt that by the poor in the Papal States it was known as Cardinal de Lugo's Powder. Chifflet, physician to the Viceroy of the Netherlands in 1653, writing dispassionately regarding the new remedy, for which he uses only the Spanish-Peruvian trade-names, speaks of its regular import to Seville and its transport thence to Rome, as established practices, and adds that it had been brought from Rome to Belgium by Jesuit Fathers: also that at least one consignment had reached Antwerp direct from Lima. By 1655 we find that both in Brussels and in Antwerp it was familiarly known as Jesuits' Powder, and we know that by 1658 "the excellent powder known by the name of the Jesuits' Powder," was being imported to this country by an English merchant domiciled in Antwerp. Whatever may have been the case in Spain or France, it is certain that those who suffered from